Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 29, Issue 9, Pages 1509-1514Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2015.1052398
Keywords
Feto-maternal immune tolerance; genetic risk; obstetrical complications; pregnancy pathology; successful placentation
Categories
Funding
- Fondazione Giorgio Pardi
- ASM (Associazione Italiana per lo Studio delle Malformazioni)
- Italian Ministry of University [20102chst5_005]
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Objective: Trophoblast expression of Human Leukocyte Antigene-G (HLA-G) is essential for feto-maternal immune tolerance and successful placentation. There is contradicting evidence on the relationship between HLA-G polymorphisms and preeclampsia (PE), intrauterine growth restriction (IUGR) and pregnancy-induced hypertension (PIH). Here, we investigate the association between both maternal and fetal HLA-G 14bp insertion/deletion polymorphism and obstetrical complications.Methods: Clinical and genetic data of 282 women/fetuses (31 severe PE, 8 mild PE, 46 IUGR, 42 PIH and 155 controls) were analyzed both individually and jointly under a codominant, a dominant and a recessive model.Results: HLA-G 14bp polymorphism was not associated with obstetrical complications, considering the mother and fetus genotypes both jointly and individually.Conclusions: With this study we filled several gaps occurring in previous studies: we analyzed a very well-defined population of PE, PIH and IUGR pregnancies, considering both fetal and maternal HLA-G 14bp polymorphism, individually and jointly. Our findings showed that fetal and maternal HLA-G 14bp genotypes are not associated with increased risk for the development of obstetrical complications, suggesting that this polymorphism has no immuno-modulatory role in the development of PE, PIH or IUGR.
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