Journal
CLINICS IN LABORATORY MEDICINE
Volume 34, Issue 2, Pages 315-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cll.2014.02.006
Keywords
Galactomannan; beta-glucan; Cryptococcus antigen test; Invasive aspergillosis; Pulmonary cryptococcosis; Pneumocystis jirovecii pneumonia; Mucormycosis
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Diagnosis of invasive fungal pneumonias by conventional culture methods is difficult to assess and often delayed. Nonmolecular fungal markers have emerged as an important adjunctive tool to support their diagnosis in combination with other clinical, radiologic, and microbiological criteria of invasive fungal diseases. Concerns about the sensitivity and specificity of some tests in different patient populations should lead to warnings about their widespread use. None can identify the emerging and particularly deadly fungal pathogens responsible for mucormycosis. The role of non-molecular fungal markers should be better defined in combination with other microbiological and radiologic tools in preemptive antifungal strategies.
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