Journal
CLINICS IN LABORATORY MEDICINE
Volume 34, Issue 4, Pages 721-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cll.2014.08.001
Keywords
Reflux; Barrett esophagus; Adenocarcinoma; Microbiome; Chronic inflammation; Viruses; Bacteria; Innate immunity
Categories
Funding
- National Cancer Institute at the National Institutes of Health Human Microbiome Project [R03CA159414, R01CA159036, R01AI110372, R21ES023421, U01CA18237, UH3CA140233]
- Department of Veterans Affairs, Veterans Health Administration, Office of Research
Ask authors/readers for more resources
With the development of culture-independent technique, a complex microbiome has been established and described in the distal esophagus. The incidence of esophageal adenocarcinoma (EAC) has increased dramatically in the United States. Studies documenting an altered microbiome associated with EAC and its precedents suggest that dysbiosis may be contributing to carcinogenesis, potentially mediated by interactions with toll-like receptors. Investigations attempting to associate viruses with EAC have not been as consistent. Currently available data are cross-sectional and therefore cannot prove causal relationships. Prospectively, microbiome studies open a new avenue to the understanding of the etiology and pathogenesis of reflux disorders and EAC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available