Journal
CLINICS IN LABORATORY MEDICINE
Volume 34, Issue 4, Pages 699-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cll.2014.08.002
Keywords
Gut microbiome; Colorectal cancer; Inflammation; Carcinogenesis
Categories
Funding
- National Cancer Institute and NIH Human Microbiome Project [U01CA18237, UH3CA140233, R01CA159036, R03CA159414]
- Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development
Ask authors/readers for more resources
The cause of colorectal cancer (CRC) is multifactorial, with genetic, molecular, inflammatory, and environmental risk factors. Recently, the gut microbiota has been recognized as a new environmental contributor to CRC in both animal models and human studies. An additional, interplay of the gut microbiome with inflammation is also evident in studies that have shown that inflammation alone or the presence of bacteria/bacterial metabolites alone is not enough to promote tumorigenesis. Rather, complex interrelationships with the gut microbiome, inflammation, genetics, and other environmental factors are evident in progression of colorectal tumors.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available