Journal
CLINICS IN GERIATRIC MEDICINE
Volume 29, Issue 3, Pages 555-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cger.2013.05.006
Keywords
Senescence; Glomerulosclerosis; Glomerular filtration rate; Renal mass; Renin-angiotensin system; Renal blood flow; Functional reserve; Osmoregulation
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Aging is associated with structural and functional changes in the kidney. Structural changes include glomerulosclerosis, thickening of the basement membrane, increase in mesangial matrix, tubulointerstitial fibrosis and arteriosclerosis. Glomerular filtration rate is maintained until the fourth decade of life, after which it declines. Parallel reductions in renal blood flow occur with redistribution of blood flow from the cortex to the medulla. Other functional changes include an increase in glomerular basement permeability and decreased ability to dilute or concentrate urine.
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