Journal
CLINICS IN GERIATRIC MEDICINE
Volume 28, Issue 2, Pages 273-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cger.2012.01.007
Keywords
Pharmacokinetics; Pharmacodynamics; Aging; Elderly; Polypharmacy; Drug therapy
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Knowledge of the physiologic changes associated with aging is vital to providing optimal pharmaceutical care to geriatric patients. The absorption, distribution, metabolism, and excretion of medications are affected to varying extents by the normal aging process and by disease states commonly associated with increasing age. Additionally, altered pharmacodynamics in the elderly-the magnitude of a drug's pharmacologic effect-may increase the risk for adverse drug effects in this population. The altered action and disposition of drugs in the elderly patient should be taken into account by health care professionals to improve adherence, provide appropriate counseling, minimize side effects, and reduce medication errors.
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