Journal
CLINICS IN GERIATRIC MEDICINE
Volume 27, Issue 4, Pages 629-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cger.2011.07.008
Keywords
Aging; Neurodegenerative disease; Alzheimer's disease; Parkinson's disease; Programmed cell death; Apoptosis; Proteinopathies; Mitochondrial dysfunction; Amyloid hypothesis; Biomarkers; Neuroimaging; Risk factors for dementia
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This article reviews the current thoughts on the effects of aging on the brain. Mechanisms of neurodegeneration are discussed, particularly those associated with Alzheimer's and Parkinson's diseases. Strategies of early detection of presymptomatic disease and potential future treatments are explored. Modification of risk factors and lifestyles for disease prevention is discussed.
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