Journal
CLINICS IN GERIATRIC MEDICINE
Volume 25, Issue 2, Pages 191-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.cger.2009.01.001
Keywords
Arterial stiffness; Arterial compliance; Elderly; Pulse wave velocity; Blood pressure; Cardiovascular outcomes
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The loss of arterial compliance as a result of the aging of human vasculature is thought to contribute to the age dependent rise in isolated systolic hypertension, and is an independent predictor of all cause mortality and cardiovascular outcomes. In this article, the author's we begin by providing a brief historical perspective of the study of the pulse wave. The author's then review the physiology of the normal arterial system, the effects of aging on the arterial system and the different measures of arterial stiffness. Finally, the author's review the different studies that look at arterial stiffness in the elderly, its impact on hypertension and cardiovascular outcome, and what is currently known on how to prevent vascular stiffness.
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