Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 29, Issue 15, Pages 2518-2521Publisher
TAYLOR & FRANCIS LTD
DOI: 10.3109/14767058.2015.1092956
Keywords
Abdominal circumference; customized birthweight centiles; intra uterine growth restriction; small for gestational age
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Funding
- Translational Clinical Research (TCR) Flagship Program - National Research Foundation (NRF)
- MRC [MC_UU_12011/4] Funding Source: UKRI
- Medical Research Council [MC_UU_12011/4] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0515-10042] Funding Source: researchfish
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Background: The aim was to evaluate the ability of customized and cohort birthweight standards in discriminating intrauterine growth retardation (IUGR).Methods: Birthweights (BWs) of GUSTO singleton infants born at gestational age (GA) 35-41 weeks were converted using two standards: (a) GUSTO cohort-based BW centile adjusted for GA and baby gender; (b) customized BW percentile calculator adjusted for maternal height and weight, race, parity, GA and gender. Infants were classified into three groups: (1)<10th BW centile by customization- customized-SGA, (2)<10th BW centile by GUSTO- GUSTO-SGA; and (3)>10th BW centile by both standards - BOTH-non-SGA.Results: Of the 1011 infant-mother dyads, 68 were customized-SGA and 104 were GUSTO-SGA, with concordance of 61% (n= 63) for SGA. While 5 (7%) of customized-SGA were not SGA by GUSTO-charts, 41 (39%) of GUSTO-SGA were not SGA by customized-charts. Customized-SGA had significantly the least growth in abdominal circumference (AC) and highest head circumference (HC): AC growth ratio between second and third trimester; and the lowest mean BW, ponderal index and placental weight than other groups.Conclusion: Customized-SGA standard was a better discriminator of pathologic fetal growth based on AC growth. It improved strength of association with pathology and in our population reduced false positives (41/104=39%) in the assessment of SGA.
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