Journal
CLINICS IN CHEST MEDICINE
Volume 35, Issue 1, Pages 71-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2013.10.004
Keywords
Inflammation; Macrophage; Neutrophil; Oxidative stress; Cytokine; Chemokine; Autoantibody; Nuclear factor-kappa B
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Funding
- National Institute for Health Research [NF-SI-0611-10148] Funding Source: researchfish
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Chronic obstructive pulmonary disease is associated with chronic inflammation affecting predominantly lung parenchyma and peripheral airways and results in largely irreversible and progressive airflow limitation. This inflammation is characterized by increased numbers of alveolar macrophages, neutrophils, and T lymphocytes, which are recruited from the circulation. Oxidative stress plays a key role in driving this inflammation. The pulmonary inflammation may enhance the development and growth of lung cancer. The peripheral inflammation extends into the circulation, resulting in systemic inflammation with the same inflammatory proteins. Systemic inflammation may worsen comorbidities. Treatment of pulmonary inflammation may therefore have beneficial effects.
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