Journal
CLINICS IN CHEST MEDICINE
Volume 35, Issue 1, Pages 87-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2013.09.012
Keywords
Infection in COPD; Airway colonization; Chronic infection; New strain exacerbations; Pneumonia and COPD; Innate immunity in COPD; Virulence factors; Vicious-circle hypothesis
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Funding
- VA Merit Review
- NHLBI
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This article represents a review of the current literature on the role of infection in the pathogenesis of chronic obstructive pulmonary disease (COPD), in stable disease, exacerbations, and pneumonia. It outlines the complex interactions between respiratory pathogens and host immune defenses that underlie the clinical manifestations of infection in COPD.
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