Journal
CLINICS IN CHEST MEDICINE
Volume 29, Issue 4, Pages 617-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2008.06.010
Keywords
Sepsis; Compensatory anti-inflammatory response syndrome; Anergy; Systemic inflammatory response syndrome; Anti-inflammatory; Human leukocyte antigen
Categories
Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM046354] Funding Source: NIH RePORTER
- NIGMS NIH HHS [R01 GM046354-15A2, R01 GM046354] Funding Source: Medline
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Like the systemic inflammatory response syndrome (SIRS), the compensatory anti-inflammatory response syndrome (CARS) is a complex pattern of immunologic responses to severe infection or injury. The difference is that while SIRS is a proinflammatory response tasked with killing infectious organisms through activation of the immune system, CARS is a global deactivation of the immune system tasked with restoring homeostasis. Much research now suggests that the timing and relative magnitude of this response have a profound impact on patient outcomes.
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