Journal
CLINICAL TRANSPLANTATION
Volume 24, Issue -, Pages 2-5Publisher
WILEY
DOI: 10.1111/j.1399-0012.2010.01268.x
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Funding
- NHLBI NIH HHS [P01 HL018646] Funding Source: Medline
- NIDDK NIH HHS [U19 DK080652] Funding Source: Medline
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Induction of donor-specific tolerance has been an ultimate goal in organ transplantation. Although numerous regimens for the induction of allograft tolerance have been developed in rodents, their application to primates has been limited. The approaches that have been successfully applied in primates can be divided into (i) use of total lymphoid irradiation, (ii) costimulatory blockade, (iii) profound depletion of recipient T cells, (iv) infusion of regulatory cells and (v) donor bone marrow (DBM) infusion/transplantation. Among these approaches, successful allograft tolerance has been achieved in clinical kidney transplantation using DBM transplantation.
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