4.3 Article

Hypoglycaemia: A little known effect of Venlafaxine overdose

Journal

CLINICAL TOXICOLOGY
Volume 50, Issue 3, Pages 215-217

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.3109/15563650.2012.660696

Keywords

Metabolic; Perfusion; CNS; Psychological

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We report the case of a 39-year-old woman who presented with serotonin syndrome and hypoglycaemia likely due to intoxication with a very high dose of venlafaxine. This case of venlafaxine-associated hypoglycaemia was treated first by glucose perfusion, but despite large doses, hypoglycaemia recurred. Blood glucose normalized after injection of octreotide, eliminating the need for hypertonic glucose. Octreotide has been shown to decrease glucose requirements and the number of hypoglycaemic episodes in patients with sulfonylurea-induced hypoglycaemia but, to our knowledge, its ability to resolve hypoglycaemic episodes due to massive venlafaxine overdose has not yet been described.

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