Journal
CLINICAL SCIENCE
Volume 122, Issue 9-10, Pages 439-447Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20110159
Keywords
diagnosis; hypertension; kidney; microRNA (miRNA); therapy; translational research
Categories
Funding
- National Institutes of Health [HL085267, DK084405, HL077263, HL082798, HL029587]
- National Research Service
- Kern Family Foundation
- American Heart Association
Ask authors/readers for more resources
MicroRNA research in humans and mammalian model organisms is in a crucial stage of development. Diagnostic and therapeutic values of microRNAs appear promising, but remain to be established. The physiological and pathophysiological significance of microRNAs is generally recognized, but much better understood in some organ systems and disease areas than others. In the present paper, we review several translational studies of microRNAs, including those showing the potential value of therapeutic agents targeting microRNAs and diagnostic or prognostic microRNA markers detectable in body fluids. We discuss the lessons learned and the experience gained from these studies. Several recent studies have begun to explore translational microRNA research in kidney disease and hypertension. Translational research of microRNAs in the kidney faces unique challenges, but provides many opportunities to develop and apply new methods, and to merge complementary basic and clinical approaches.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available