Journal
CLINICAL SCIENCE
Volume 116, Issue 5-6, Pages 451-465Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20080502
Keywords
cancer; inflammation; intracellular signalling; nuclear factor kappa B (NF-kappa B); Rel
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Funding
- Agency for Science Technology and Research (A Star), Singapore
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The NF-kappa B (nuclear factor kappa B) family of transcription factors are involved in a myriad of activities, including the regulation of immune responses, maturation of immune cells, development of secondary lymphoid organs and osteoclastogenesis. Fine tuning by positive and negative regulators keeps the NF-kappa B signalling pathway in check. Microbial products and genetic alterations in NF-kappa B and other signalling pathway components can lead to deregulation of NF-kappa B signalling in several human diseases, including cancers and chronic inflammatory disorders. NF-kappa B-pathway-specific therapies are being actively investigated, and these hold promises as interventions of NF-kappa B-related ailments.
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