Journal
CLINICAL SCIENCE
Volume 116, Issue 5-6, Pages 391-399Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20080272
Keywords
blood pressure; cardiac myocyte; G-protein-coupled receptor; heterotrimeric GTP-binding protein; regulator of G-protein signalling (RGS); vascular smooth muscle cell
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Funding
- Canadian Institutes of Health Research [MOP-79466]
- Canadian Institutes of Health Research
- Frederick Banting and Charles Best Canada
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Understanding the mechanisms that underlie BP (blood pressure) variation in humans and animal models may provide important clues for reducing the burden of uncontrolled hypertension in industrialized societies. High BP is often associated with increased signalling via G-protein-coupled receptors. Three members of the RGS (regulator of G-protein signalling) superfamily RGS2, RGS4 and RGS5 have been implicated in the attenuation of G-protein signalling pathways in vascular and cardiac myocytes, as well as cells of the kidney and autonomic nervous system. In the present review, we discuss the current state of knowledge regarding their differential expression and function in cardiovascular tissues, and the likelihood that one or more of these alleles are candidate hypertension genes. Together, findings from the studies described herein suggest that development of methods to modulate the expression and function of RGS proteins may be a possible strategy for the treatment and prevention of hypertension and cardiovascular disease.
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