Journal
CLINICAL SCIENCE
Volume 116, Issue 3-4, Pages 191-203Publisher
PORTLAND PRESS LTD
DOI: 10.1042/CS20080113
Keywords
cancer; cardiovascular disease; diabetes; forkhead box (Fox); immune system; oxidative stress; stem cell
Categories
Funding
- American Diabetes Association
- American Heart Association
- Bugher Foundation Award
- Janssen Neuroscience Award
- LEARN Foundation Award
- MI Life Sciences Challenge Award
- Nelson Foundation Award
- National Institutes of Health National Institute of Environmental Health Sciences [P30 ES06639]
- National Institutes of Health National Institute of Neurological Disorders and Stroke/National Institute of Aging
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Dysfunction in the cardiovascular system can lead to the progression of a number of disease entities that can involve cancer, diabetes, cardiac ischaemia, neurodegeneration and immune system dysfunction. In order for new therapeutic avenues to overcome some of the limitations of present clinical treatments for these disorders, future investigations must focus upon novel cellular processes that control cellular development, proliferation, metabolism and inflammation. In this respect, members of the mammalian forkhead transcription factors of the O class (FoxOs) have increasingly become recognized as important and exciting targets for disorders of the cardiovascular system. In the present review, we describe the role of these transcription factors in the cardiovascular system during processes that involve angiogenesis, cardiovascular development, hypertension, cellular metabolism, oxidative stress, stem cell proliferation, immune system regulation and cancer. Current knowledge of FoxO protein function combined with future studies should continue to lay the foundation for the successful translation of these transcription factors into novel and robust clinical therapies.
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