Journal
CLINICAL RHEUMATOLOGY
Volume 30, Issue 3, Pages 409-413Publisher
SPRINGER LONDON LTD
DOI: 10.1007/s10067-010-1640-y
Keywords
Interleukin-6; Portuguese Caucasian; Systemic lupus erythematosus
Categories
Funding
- Fundacao para a Ciencia e a Tecnologia, Portugal [PIC/IC/82920/2007]
- Wyeth Portugal
- Fundação para a Ciência e a Tecnologia [PIC/IC/82920/2007] Funding Source: FCT
Ask authors/readers for more resources
Interleukin-6 (IL-6) is a multifunctional cytokine with an important pathophysiological role in systemic lupus erythematosus (SLE). The polymorphism of the IL-6 gene promoter at position -174, which appears to influence the production of this cytokine, has been associated with susceptibility to some rheumatic diseases. The aim of this study is to investigate whether the IL-6 -174 G/C polymorphism associates with lupus susceptibility or affects disease characteristics in Portuguese patients with SLE. The association between -174 G/C and lupus diagnosis was studied in 115 adult SLE patients (95.7% females) and 152 healthy controls (94.7% females), all Caucasians. There were no significant differences in genotype or allele frequency between patients and controls. The -174 C/C genotype was independently associated with renal disease and the C allele with the presence of irreversible damage. The IL-6 gene promoter polymorphism at position -174 does not contribute to SLE susceptibility in Portuguese Caucasian patients but may predispose to specific manifestations of the disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available