Journal
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
Volume 38, Issue 2-3, Pages 90-96Publisher
HUMANA PRESS INC
DOI: 10.1007/s12016-009-8142-1
Keywords
Elderly patients; LORHEN database; Adverse events; Elderly-onset rheumatoid arthritis; Younger-onset rheumatoid arthritis
Categories
Funding
- Schering-Plough
- Weyth
- Abbot
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This study aims to compare the efficacy and safety of anti-TNF agents in elderly (aged a parts per thousand yen65 years) and younger patients (aged 18-65 years) with active RA. The study involved 1,114 RA patients treated with anti-TNF drugs and followed-up for > 6 months by LORHEN group, who were divided into two cohorts on the basis of their age (311 aged a parts per thousand yen65 and 803 aged < 65 years) in order to evaluate 3-year outcomes and treatment discontinuations. Drug effectiveness was assessed by disease activity (DAS28 and EULAR response), functional status (HAQ) and serological parameters (ESR) at baseline and during anti-TNF alpha therapy; safety was evaluated on the basis of drug discontinuation rates. At baseline, the elderly patients showed greater disease activity (DAS28, ESR) and loss of joint function (HAQ, functional class; p < 0.05). During therapy, clinical and laboratory parameters (DAS28, ESR) improved in both groups without any statistically significant difference between them, whereas the difference in HAQ remained after 36 months of treatment (p < 0.05). Anti-TNF alpha therapy was discontinued by 123 of the elderly (42%) and 282 of the younger patients (36.6%) because of loss of efficacy (17.4% vs. 16.7%), severe adverse events (21.8% vs. 16.9%) or other reasons (2.7% vs. 3%). The number of adverse events was significantly higher in the elderly patients (p < 0.05). Anti-TNF alpha treatment reduced disease activity and led to functional improvement in both groups, although the baseline difference in HAQ remained statistically significant at the end of the follow-up. The elderly patients experienced more infective events.
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