Journal
CLINICAL RESPIRATORY JOURNAL
Volume 4, Issue -, Pages 15-19Publisher
WILEY-BLACKWELL PUBLISHING, INC
DOI: 10.1111/j.1752-699X.2010.00192.x
Keywords
airways; basement membrane; ECP; eosinophil; fibrosis; laminin; TGF beta
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Funding
- GlaxoSmithKline
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Objectives: Eosinophils are common findings cells in allergic asthma as is sub-base membrane thickening of the airways. The objective of this review was to summarise some recent findings linking the activities of eosinophils to airways remodelling. Data Source and Study Selection: The study used a review of current literature with emphasis on our own recent findings. Results: Eosinophils are found at increased numbers in asthma and more so in allergic as compared with non-allergic asthma. A link has been found in several clinical studies on allergic asthmatics, but not in studies on non-allergic asthma, between the presence of eosinophils and signs of airways remodelling. The eosinophil contains and secretes several pro-fibrogenic molecules such as eosinophil cationic protein (ECP) and transforming growth factor beta (TGF-beta). Genetic studies on subjects developing liver fibrosis as a consequence of Schistosoma mansoni infection show close relationships to ECP genotypes. Conclusion: Several clinical and experimental studies indicate that eosinophils contribute to airways remodelling not only through their secretion of cationic proteins such as ECP and cytokines such as TGF-beta 1, but also through interactions with mast cells and epithelial cells. Please cite this paper as: Venge P. The eosinophil and airway remodelling in asthma. Clin Respir J 2010; 4 (Suppl. 1): 15-19.
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