Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 96, Issue 4, Pages 464-469Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2014.147
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Funding
- NIA NIH HHS [K23 AG042492, R01 AG032289] Funding Source: Medline
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The role of inflammation in cognitive decline has generated considerable interest, although few longitudinal evaluations have been conducted. A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes. The directionality, magnitude, and progression of these associations remain unclear. Future studies employing multiple time points of inflammatory data along with Alzheimer's disease (AD) biomarkers are critical for explication of longitudinal inflammation in cognitive decline.
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