Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 94, Issue 1, Pages 23-26Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2013.12
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Funding
- NIGMS NIH HHS [U19 GM061390, U01 GM061390] Funding Source: Medline
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This Commentary focuses on genetic polymorphisms in membrane transporters. We present two polymorphisms for which there is a compelling body of literature supporting their clinical relevance: OATP1B1 (c.521T>C, p.V174A, rs4149056) and BCRP (c.421C>A, p.Q141K, rs2231142). The clinical evidence demonstrating their role in variation in pharmacokinetics and pharmacodynamics is described along with their allele frequencies in ethnic populations. Recommendations for incorporating studies of transporter polymorphisms in drug development are provided, along with the regulatory implications.
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