Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 94, Issue 1, Pages 95-112Publisher
WILEY
DOI: 10.1038/clpt.2013.81
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Funding
- National Institutes of Health from the National Institute of General Medical Sciences [R01GM41935]
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This white paper addresses current approaches and knowledge gaps concerning methods to assess the role of transport proteins in drug/metabolite disposition in humans. The discussion focuses on in vitro tools to address key questions in drug development, including vesicle- and cell-based systems. How these methods can be used to assess the liability of compounds for transporter-based drug-drug interactions (DDIs) in vivo is also explored. Existing challenges and approaches to examine the involvement of transporters in drug disposition are discussed.
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