Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 95, Issue 3, Pages 258-261Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2013.220
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Funding
- German Federal Ministry of Education and Research (Virtual Liver Network grant) [0315755]
- European Union's 7FP Training Network program, Fighting Drug Failure [GA-238132]
- Robert Bosch Foundation, Stuttgart, Germany
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Of 57 functional human cytochrome P450 (CYP) isoforms, about a dozen liver-expressed, highly variable forms are responsible for the biotransformation of most drugs. Owing to numerous genetic and nongenetic sources of variation, each individual possesses his/her own, rather unique, CYP profile. Here, we explore the potential of new technologies and developments in genetics, epigenetics, and the regulation of gene expression to increase our understanding of the mechanisms that lead to the enormous inter-and intraindividual variability of these enzymes.
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