Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 94, Issue 1, Pages 126-141Publisher
WILEY
DOI: 10.1038/clpt.2013.78
Keywords
-
Categories
Funding
- National Institutes of Health from the National Institute of General Medical Sciences [R01GM41935, R01GM078200, R01GM104178]
Ask authors/readers for more resources
Intracellular concentrations of drugs and metabolites are often important determinants of efficacy, toxicity, and drug interactions. Hepatic drug distribution can be affected by many factors, including physicochemical properties, uptake/efflux transporters, protein binding, organelle sequestration, and metabolism.This white paper highlights determinants of hepatocyte drug/metabolite concentrations and provides an update on model systems, methods, and modeling/simulation approaches used to quantitatively assess hepatocellular concentrations of molecules. The critical scientific gaps and future research directions in this field are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available