Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 93, Issue 4, Pages 299-301Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2012.236
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Current drug discovery strategies include both molecular and empirical approaches. The molecular approaches are predominantly hypothesis-driven and are referred to as target-based. The empirical approaches are referred to as phenotypic because they rely on phenotypic measures of response. A recent analysis revealed the phenotypic approaches to be the more successful strategy for small-molecule, first-in-class medicines. The rationalization for this success was the unbiased identification of the molecular mechanism of action (MMOA).
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