Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 94, Issue 1, Pages 3-9Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2013.86
Keywords
-
Categories
Ask authors/readers for more resources
More than 400 membrane transporters in two major superfamilies-ATP-binding cassette (ABC) and solute carrier (SLC)-are annotated in the human genome. Preclinical and clinical studies indicate that transport is an important determinant of drug disposition, as well as therapeutic and adverse drug effects. Importantly, transporters may represent the rate-determining step of drug absorption, distribution, and elimination in the intestine, liver, kidney, and blood-brain barrier (BBB), and they are often the sites of drug-drug interactions.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available