Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 91, Issue 3, Pages 467-474Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2011.248
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Funding
- National Research Foundation of Korea (NRF)
- Korean government (MEST) [2010-0023402, 2011-0018258]
- National Research Foundation of Korea [2010-0023402] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Electronic health records (EHRs) are expected to be a good source of data for pharmacovigilance. However, current quantitative methods are not applicable to EHR data. We propose a novel quantitative postmarketing surveillance algorithm, the Comparison of Laboratory Extreme Abnormality Ratio (CLEAR), for detecting adverse drug reaction (ADR) signals from EHR data. The methodology involves calculating the odds ratio of laboratory abnormalities between a specific drug-exposed group and a matched unexposed group. Using a 10-year EHR data set, we applied the algorithm to test 470 randomly selected drug-event pairs. It was found possible to analyze a single drug-event pair in just 109 +/- 159 seconds. In total, 120 of the 150 detected signals corresponded with previously reported ADRs (positive predictive value (PPV) = 0.837 +/- 0.113, negative predictive value (NPV) = 0.659 +/- 0.180). By quickly and efficiently identifying ADR signals from EHR data, the CLEAR algorithm can significantly contribute to the utilization of EHR data for pharmacovigilance.
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