Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 89, Issue 5, Pages 655-661Publisher
WILEY
DOI: 10.1038/clpt.2011.38
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Funding
- Japan Society for the Promotion of Science (JSPS) [21591079]
- Ministry of Education, Culture, Sports, Science and Technology (MEXT)
- Yamanaka iPS cell special project
- Core Research for Evolutional Science and Technology (CREST)
- Ministry of Health and Labour
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22110007]
- Takeda Science Foundation
- Kanae Foundation for the Promotion of Medical Science
- NOVARTIS Foundation for Gerontological Research
- Grants-in-Aid for Scientific Research [22110007, 21591079] Funding Source: KAKEN
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Induced pluripotent stem cell (iPSC) technology is revolutionizing medical science, allowing the exploration of disease mechanisms and novel therapeutic molecular targets, and offering opportunities for drug discovery and proof-of-concept studies in drug development. This review focuses on the recent advancements in iPSC technology including disease modeling and control setting in its analytical paradigm. We describe how iPSC technology is integrated into existing paradigms of drug development and discuss the potential of iPSC technology in personalized medicine.
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