iPS Cells in Type 1 Diabetes Research and Treatment

Induced pluripotent stem (iPS) cells, with their ability to differentiate into every cell type of the body, represent a perfect source for cell-replacement therapies in type 1 diabetes (T1D). Hence, there is a need to optimize the differentiation protocols to generate fully glucose-responsive and mature cells. In addition, the use of iPS cells could make possible the generation of patient-specific disease models that could further our understanding of the root cause of autoimmune diabetes.