Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 91, Issue 1, Pages 21-29Publisher
WILEY
DOI: 10.1038/clpt.2011.262
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The term cellular senescence denotes a cellular response to several stressors that results in irreversible growth arrest, alterations of the gene expression profile, epigenetic modifications, and an altered secretome, all of which eventually impair the reparative properties of primitive cells, adding a layer of complexity to the field of regenerative medicine. The purpose of this review is to illustrate how cellular senescence could affect tissue repair and to propose interventions that aim at interfering with it.
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