A New Trend in Personalized Medicine: Rapid Detection of SNPs in Drug Transporter Genes by the SmartAmp Method

Clinical validation of genetic polymorphisms and the development of new technologies for the rapid detection of clinically important variants are critical issues in the advancement of personalized medicine. The Smart Amplification (SmartAmp) process was recently developed as a rapid and cost-effective method that enables rapid detection of genetic polymorphisms within similar to 40 min, under isothermal conditions, and without the need for DNA isolation or polymerase chain reaction (PCR) amplification.(1) This article addresses the molecular mechanisms involved in the SmartAmp method and its clinical applications.