Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 84, Issue 6, Pages 715-721Publisher
WILEY
DOI: 10.1038/clpt.2008.139
Keywords
-
Categories
Funding
- National Institutes of Health [HL074730, HL69758, RR017568]
- Abbott Pharmaceuticals
- American Heart Association [0625619B]
Ask authors/readers for more resources
Numerous studies have demonstrated that beta(1)- and beta(2)-adrenergic receptor gene (ADRB1 and ADRB2) variants influence cardiovascular risk and beta-blocker responses in hypertension and heart failure. We evaluated the relationship between ADRB1 and ADRB2 haplotypes, cardiovascular risk (death, nonfatal myocardial infarction (MI), and nonfatal stroke), and atenolol-based vs. verapamil sustained-release (SR)-based antihypertensive therapy in 5,895 coronary artery disease (CAD) patients. after an average of 2.8 years, death rates were higher in patients carrying the ADRB1 ser49-arg389 haplotype (hazard ratio (HR) 3.66,95% confidence interval (95% CI) 1.68-7.99). This mortality risk was significant in patients randomly assigned to verapamil SR (HR 8.58,95% CI 2.06-35.8) but not atenolol (HR 2.31,95% CI 0.82-6.55), suggesting a protective role for the beta-blocker. ADRB2 haplotype associations were divergent within the treatment groups but did not remain significant after adjustment for multiple comparisons. ADRB1 haplotype variation is associated with mortality risk, and beta-blockers may be preferred in subgroups of patients defined by ADRB1 or ADRB2 polymorphisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available