Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 84, Issue 4, Pages 462-467Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/clpt.2008.64
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Funding
- Turku University Hospital [EVO 13821]
- Instrumentarium Foundation, Finland
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We compared the pharmacokinetics of 10 mg oral oxycodone in four groups of 10 patients each, aged 20-40, 60-70, 70-80, and 80-90 years. Patients aged 70-80 and 80-90 years had 50-80% higher mean exposure to oxycodone (P < 0.05) and a twofold higher plasma oxycodone concentration (P < 0.05) than the young adults 12 h after ingestion of the drug. Because oxycodone pharmacokinetics depend to a great extent on the age of the subject, it is important to titrate the analgesic dose individually, particularly in the elderly.
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