Journal
CLINICAL PHARMACOLOGY & THERAPEUTICS
Volume 85, Issue 2, Pages 217-221Publisher
WILEY
DOI: 10.1038/clpt.2008.200
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It is estimated that the development of a new anticancer agent costs US$800 million to 1 billion and takes more than a decade between conception and approval.(1) However, 90% of novel antineoplastic drugs fail in the clinic despite evidence of antitumor efficacy in classical preclinical models.(2) This raises serious concerns as to whether such models are predictive of drug efficacy in humans, particularly in the current era of new targeted therapies, and supports the development of alternative approaches.
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