Related references
Note: Only part of the references are listed.Physiologically based pharmacokinetic modelling and in vivo [I]/Ki accurately predict P-glycoprotein-mediated drug-drug interactions with dabigatran etexilate
Yuansheng Zhao et al.
BRITISH JOURNAL OF PHARMACOLOGY (2014)
Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations
Vicky Hsu et al.
CLINICAL PHARMACOKINETICS (2014)
Evaluation of Various Static In Vitro-In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug
Md L. T. Vieiral et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)
Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data
H. J. Einolfl et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2014)
Identification of alcohol-dependent clopidogrel metabolites using conventional liquid chromatography/triple quadrupole mass spectrometry
Zhe-Yi Hu et al.
RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2014)
Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors
Lyudmila G. Tsurkan et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Genetic Determinants of Dabigatran Plasma Levels and Their Relation to Bleeding
Guillaume Pare et al.
CIRCULATION (2013)
Evaluation of the Inhibitory Effects of Antihypertensive Drugs on Human Carboxylesterase In Vitro
Xu Yanjiao et al.
DRUG METABOLISM AND PHARMACOKINETICS (2013)
Neuropsychiatric Adverse Events and Oseltamivir for Prophylaxis
Mark Jones et al.
DRUG SAFETY (2013)
Modulation of Esterified Drug Metabolism by Tanshinones from Salvia miltiorrhiza (Danshen)
M. Jason Hatfield et al.
JOURNAL OF NATURAL PRODUCTS (2013)
Simple and sensitive assay for quantification of oseltamivir and its active metabolite oseltamivir carboxylate in human plasma using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry: Improved applicability to pharmacokinetic study
Zhe-Yi Hu et al.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2013)
The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response
Joshua P. Lewis et al.
PHARMACOGENETICS AND GENOMICS (2013)
The Role of Human Carboxylesterases in Drug Metabolism: Have We Overlooked Their Importance?
S. Casey Laizure et al.
PHARMACOTHERAPY (2013)
Carboxylesterase 1 as a Determinant of Clopidogrel Metabolism and Activation
Hao-Jie Zhu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2013)
Differential Influences of Ethanol on Early Exposure to Racemic Methylphenidate Compared with Dexmethylphenidate in Humans
Kennerly S. Patrick et al.
DRUG METABOLISM AND DISPOSITION (2013)
Safety, Tolerability, and Pharmacokinetics of Intravenous Oseltamivir: Single- and Multiple-Dose Phase I Studies with Healthy Volunteers
Barbara J. Brennan et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2012)
Carboxylesterase 1 Polymorphism Impairs Oseltamivir Bioactivation in Humans
E. K. Tarkiainen et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
Physiologically Based Pharmacokinetics Joined With In Vitro-In Vivo Extrapolation of ADME: A Marriage Under the Arch of Systems Pharmacology
A. Rostami-Hodjegan
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
Intestinal Absorption and Presystemic Elimination of Various Chemical Constituents Present in GBE50 Extract, a Standardized Extract of Ginkgo biloba Leaves
Li Li et al.
CURRENT DRUG METABOLISM (2012)
CYP2C metabolism of oral antidiabetic drugs - impact on pharmacokinetics, drug interactions and pharmacogenetic aspects
Andreas Holstein et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2012)
Species difference of esterase expression and hydrolase activity in plasma
Fatma Goksin Bahar et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Evolution of a detailed physiological model to simulate the gastrointestinal transit and absorption process in humans, part II: Extension to describe performance of solid dosage forms
Kirstin Thelen et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2012)
Prediction and In Vitro Evaluation of Selected Protease Inhibitor Antiviral Drugs as Inhibitors of Carboxylesterase 1: A Potential Source of Drug-Drug Interactions
Jenna A. Rhoades et al.
PHARMACEUTICAL RESEARCH (2012)
Using Expression Data for Quantification of Active Processes in Physiologically Based Pharmacokinetic Modeling
Michaela Meyer et al.
DRUG METABOLISM AND DISPOSITION (2012)
Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants
Neil Parrott et al.
CLINICAL PHARMACOKINETICS (2011)
Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review
P. Zhao et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2011)
Evolution of a Detailed Physiological Model to Simulate the Gastrointestinal Transit and Absorption Process in Humans, Part 1: Oral Solutions
Kirstin Thelen et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2011)
Predictions of Metabolic Drug-Drug Interactions Using Physiologically Based Modelling Two Cytochrome P450 3A4 Substrates Coadministered with Ketoconazole or Verapamil
Nathalie Perdaems et al.
CLINICAL PHARMACOKINETICS (2010)
The Effect of Ethanol on Oral Cocaine Pharmacokinetics Reveals an Unrecognized Class of Ethanol-Mediated Drug Interactions
Robert B. Parker et al.
DRUG METABOLISM AND DISPOSITION (2010)
Identification of selected therapeutic agents as inhibitors of carboxylesterase 1: Potential sources of metabolic drug interactions
Hao-Jie Zhu et al.
TOXICOLOGY (2010)
Pharmacokinetics of High-Dose Oseltamivir in Healthy Volunteers
Y. Wattanagoon et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2009)
Activation of the Antiviral Prodrug Oseltamivir Is Impaired by Two Newly Identified Carboxylesterase 1 Variants
Hao-Jie Zhu et al.
DRUG METABOLISM AND DISPOSITION (2009)
IC50-to-Ki: a web-based tool for converting IC50 to Ki values for inhibitors of enzyme activity and ligand binding
R. Z. Cer et al.
NUCLEIC ACIDS RESEARCH (2009)
Use of Physiologically Based Biokinetic (PBBK) Modeling to Study Estragole Bioactivation and Detoxification in Humans as Compared with Male Rats
Ans Punt et al.
TOXICOLOGICAL SCIENCES (2009)
Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: Clinical significance and molecular basis
Hao-Jie Zhu et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2008)
Neuroexcitatory actions of Tamiflu and its carboxylate metabolite
Yukitoshi Izumi et al.
NEUROSCIENCE LETTERS (2007)
Mechanistic approaches to volume of distribution predictions: Understanding the processes
Trudy Rodgers et al.
PHARMACEUTICAL RESEARCH (2007)
Influence of ethanol and gender on methylphenidate pharmacokinetics and pharmacodynamics
K. S. Patrick et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
Drug interaction studies: Study design, data analysis, and implications for dosing and labeling
S-M Huang et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2007)
Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol
Man Tang et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Anti-influenza prodrug oseltamivir is activated by carboxylesterase human carboxylesterase 1, and the activation is inhibited by antiplatelet agent clopidogrel
Deshi Shi et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2006)
Physiologically based pharmacokinetic modelling 2: Predicting the tissue distribution of acids, very weak bases, neutrals and zwitterions
Trudy Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2006)
Human carboxylesterase isozymes: Catalytic properties and rational drug design
Teruko Imai
DRUG METABOLISM AND PHARMACOKINETICS (2006)
Physiologically based pharmacokinetic modeling 1: Predicting the tissue distribution of moderate-to-strong bases
T Rodgers et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2005)
A physiologically based model for ethanol and acetaldehyde metabolism in human beings
DM Umulis et al.
ALCOHOL (2005)
Current progress on esterases: From molecular structure to function
T Satoh et al.
DRUG METABOLISM AND DISPOSITION (2002)