Journal
CLINICAL PEDIATRICS
Volume 53, Issue 1, Pages 71-81Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0009922813500846
Keywords
Hirschsprung disease; congenital megacolon; aganglionosis; enteric nervous system; Hirschsprung-associated enterocolitis; genetics; intestinal neuronal dysplasia
Categories
Funding
- NIH [5K08DK090281-03]
Ask authors/readers for more resources
Hirschsprung disease (HSCR) is a multigenic condition with variable presentation. Most commonly, it presents in the neonatal period as a functional intestinal obstruction secondary to failure of caudal migration of the enteric nervous system. Classically, this manifests as dilated proximal bowel and constricted distal bowel with absent ganglia and hypertrophic nerve trunks. When recognized early, medical and surgical therapies can be instituted to minimize associated morbidity and mortality. This article reviews current understanding of the etiology of HSCR, its multigenic associations, the historical evolution of HSCR diagnosis and treatment, and current HSCR therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available