Journal
ACS NANO
Volume 9, Issue 4, Pages 4390-4397Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.5b00877
Keywords
resistive-pulse; pore; rod; rotation; excluded volume; electroosmosis
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Funding
- National Science Foundation [CHE 1306058]
- China Scholarship Council [CSC 201406090034]
- NSF [DMR-1352218]
- Stichting voor Fundamenteel Onderzoek der Materie (FOM)
- Direct For Mathematical & Physical Scien [1306058] Funding Source: National Science Foundation
- Division Of Chemistry [1306058] Funding Source: National Science Foundation
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The resistive-pulse technique has been used to detect and size objects which pass through a single pore. The amplitude of the ion current change observed when a particle is in the pore is correlated with the particle volume. Up to date, however, the resistive-pulse approach has not been able to distinguish between objects of similar volume but different shapes. In this manuscript, we propose using pores with longitudinal irregularities as a sensitive tool capable of distinguishing spherical and rod-shaped particles with different lengths. The ion current modulations within resulting resistive pulses carry information on the length of passing objects. The performed experiments also indicate the rods rotate while translocating, and displace an effective volume that is larger than their geometrical volume, and which also depends on the pore diameter.
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