Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 55, Issue 4, Pages 1498-1501Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201509840
Keywords
allylic compounds; boron; copper; N-heterocyclic carbenes; regioselectivity
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2015R1C1A1A02036326]
- POSTECH
Ask authors/readers for more resources
Reported herein is a copper-catalyzed S(N)2'-selective allylic substitution reaction using readily accessible allylic chlorides and 1,1-diborylalkanes, a reaction which proceeds with chemoselective C-B bond activation of the 1,1-diborylalkanes. In the presence of a catalytic amount of [Cu(IMes) Cl] [IMes=1,3-bis(2,4,6-trimethylphenyl) imidazole-2-ylidene] and LiOtBu as a base, a range of primary and secondary allylic chlorides undergo the S(N)2'-selective allylic substitution reaction to produce branched alkylboronates. The synthetic utilities of the obtained alkylboronates are also presented.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available