Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 54, Issue 40, Pages 11647-11651Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201501461
Keywords
dendrimers; fluorine; gene delivery; self-assembly
Categories
Funding
- NSFC [21322405, 21474030]
- Shanghai Municipal Science and Technology Commission [13A1401500, 148014518]
Ask authors/readers for more resources
An ideal vector in gene therapy should exhibit high serum stability, excellent biocompatibility, a desired transfection efficacy and permeability into targeted tissues. Here, we describe a class of low-molecular-weight fluorodendrimers for efficient gene delivery. These materials self-assemble into uniform nanospheres and allow for efficient transfection at low charge ratios and very low DNA doses with minimal cytotoxicity. Our results demonstrate that these vectors combine the features of synthetic gene vectors such as liposomes and cationic polymers and present promising potential for clinical gene therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available