Journal
CLINICAL ORAL IMPLANTS RESEARCH
Volume 24, Issue 12, Pages 1360-1368Publisher
WILEY
DOI: 10.1111/clr.12033
Keywords
alveolar process; bone remodeling; CD68 antigen; growth factors; histology; osteocalcin; plasma; platelet-rich plasma; tooth extraction; von Willebrand factor
Funding
- Research Center for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara
- Regione Emilia-Romagna (Programma Ricerca Regione - Universita)
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ObjectivesTo determine whether and to what extent the additional application of plasma rich in growth factors (PRGF) to an extraction socket may influence the early bone deposition, as assessed by micro-computed tomography (micro-CT) scan as well as histomorphometric markers. Material and methodsTwenty-eight patients (age range: 34-74years) contributing 36 extraction sockets were included in the study. Sockets were either treated with PRGF (PRGF group; 18 sites in 11 patients) or left to spontaneous healing (control group; 18 sites in 17 patients). Radiographic and histomorphometric analysis was performed on bone cores trephined from each healing socket after 4-6 (T1) or 7-10 (T2) weeks of healing. ResultsPatients treated with PRGF application showed (i) similar bone volume and tissue mineral content, (ii) a trend, although not statistically significant, toward a greater number of CD68+ cells (at T1 and T2) and vVW+ cells (at T1), and (iii) a similar OCN staining score throughout the study, when compared with control group. ConclusionsPlasma rich in growth factors-treated group did not show any enhancement in early (4 and 8weeks) bone deposition compared with control group.
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