Journal
CLINICAL ONCOLOGY
Volume 26, Issue 5, Pages 277-288Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2014.02.002
Keywords
Hypoxia; hypoxia-activated prodrugs; imaging; oxygen; radiation
Categories
Funding
- Cancer Research UK (CRUK)
- EU FP7 Metoxia Grant [222741]
- CRUK Clinician Scientist Fellowship [C19221/A15267]
- CRUK
- Engineering and Physical Sciences Research Council [C8742/A018097]
- Academy of Medical Sciences (AMS) [AMS-SGCL3-OConnor] Funding Source: researchfish
- Cancer Research UK [18097, 19276, 15267] Funding Source: researchfish
- National Institute for Health Research [CL-2009-06-005] Funding Source: researchfish
Ask authors/readers for more resources
Hypoxia was identified as a microenvironmental component of solid tumours over 60 years ago and was immediately recognised as a potential barrier to therapy through the reliance of radiotherapy on oxygen to elicit maximal cytotoxicity. Over the last two decades both clinical and experimental studies have markedly enhanced our understanding of how hypoxia influences cellular behaviour and therapy response. Furthermore, they have confirmed early assumptions that low oxygenation status in tumours is an exploitable target in cancer therapy. Generally such approaches will be more beneficial to patients with hypoxic tumours, necessitating the use of biomarkers that reflect oxygenation status. Tissue biomarkers have shown utility in many studies. Further significant advances have been made in the non-invasive measurement of tumour hypoxia with positron emission tomography, magnetic resonance imaging and other imaging modalities. Here, we describe the complexities of defining and measuring tumour hypoxia and highlight the therapeutic approaches to combat it. (C) 2014 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available