Journal
CLINICAL ONCOLOGY
Volume 20, Issue 7, Pages 548-554Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.clon.2008.04.018
Keywords
chemotherapy; oncolytic virus; radiotherapy; reovirus
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Oncolytic viruses are tumour selective and able to lyse cancer cells after infection. Reovirus is an example of a wild-type oncolytic virus and is currently being investigated as a potential novel therapy for cancer. This overview gives a brief description of what is known about reovirus biology and summarises the preclinical data related to its oncolytic ability. The completed and ongoing clinical trials involving reovirus, both as a single agent and in combination with chemotherapy and radiotherapy, will be reviewed and their results discussed. Many of these clinical studies are being conducted by centres in the UK.
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