Journal
CLINICAL OBSTETRICS AND GYNECOLOGY
Volume 56, Issue 3, Pages 556-565Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GRF.0b013e318299d2a8
Keywords
maternal depression; childhood depression; programming; epigenetics; stress; developmental origins
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Funding
- National Institute of Health [R01MH094609, F32DA032175]
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The growing field of epigenetics and human behavior affords an unprecedented opportunity to discover molecular underpinnings of mental health disorders and pave the way for the development of preventive intervention programs. Maternal depression during pregnancy is a serious public health issue and leads to a 4-fold increase in the likelihood that the child will develop depression. We describe how mood disorders, particularly depression, may be shaped by early life stress, programming, and epigenetic processes and pathways showing how these processes could lead to depression in childhood. Implications of this approach to the study of mental health disorders for preventive interventions are discussed.
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