Journal
CLINICAL OBSTETRICS AND GYNECOLOGY
Volume 54, Issue 2, Pages 358-369Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GRF.0b013e318217ee18
Keywords
cerebral palsy; neurodevelopmental delay; preterm birth; preterm premature rupture of membranes (PPROM)
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There is increasing evidence that preterm premature rupture of membranes (PPROM) is associated with increased risk for adverse neurodevelopmental outcomes through multiple mechanisms, including preterm birth and its antecedent etiologies. Intrauterine infection is a particularly important risk factor for adverse neurodevelopmental outcomes after PPROM. This review focuses on the long-term neurodevelopmental outcomes after PPROM, the possible etiologic mechanisms of neurological injury, and the effect of antenatal and perinatal interventions using available evidence.
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