Journal
CLINICAL NUTRITION
Volume 32, Issue 4, Pages 503-510Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2012.12.008
Keywords
Omega-3 fatty acids; Parenteral nutrition; Surgery; Immunology; Clinical outcome
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Funding
- FAPESP [2004/06259-7, 2007/56474-0, 2008/50944-7]
- CNPq [04/50633-3]
- Fresenius-Kabi Germany
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Background: Fish oil-based lipid emulsions (FOLEs) have shown post-operative immunological and clinical benefits in parenteral nutrition. Aim: To assess post-operative immune response after short-term pre-operative parenteral infusion of isolated FOLE in gastrointestinal cancer patients. Methods: The patients (n = 63) received pre-operative peripheral infusion (0.2 g fat/kg body weight/d) of FOLE (Omegaven (R)) or control lipid emulsion (MCT/LCT; Lipovenos MCT (R)) for 3 days. Post-operative concentrations of inflammatory mediators, leukocyte functions, surface molecules, infections, and length of intensive care unit (ICU) and hospital stay were measured. Results: FOLE patients had a significant increase of IL-10 levels on day 3, decrease of IL-6 and IL-10 levels on day 6, lower decrease in leukocyte oxidative burst, maintenance of monocyte percentage expressing HLA-DR and CD32, and increase of CD32 neutrophil expression compared to MCT/LCT patients. No changes were observed in the frequency of post-operative infections or length of ICU and hospital stay. Conclusions: Short-term pre-operative infusion of FO alone improves the post-operative immune response of gastrointestinal cancer patients without significantly changing post-operative infections or length of ICU and hospital stay. ID:NCT01218841. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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