Journal
CLINICAL NUTRITION
Volume 32, Issue 2, Pages 200-206Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2012.08.022
Keywords
Red wine; Polyphenols; Alcohol; Insulin resistance; HOMA index; Lipoprotein(a)
Categories
Funding
- Ministerio de Ciencia e Innovacion (MICINN), Spain [AGL2006-14228-C03-01/02-ALI, AGL2007-66638-C02-02/ALI, AGL2009-13906-C02-02, AGL2010-22319-C03-02, PI07/0473]
- Gemma Chiva-Blanch by the Manuel de Oya fellowship program
- Palmira Valderas-Martinez by the APIF-UB fellowship program
- MICINN [CD09/00134, CD10/00151]
- Rafael Llorach by the Ramon y Cajal program from the MICINN
- Fondo Social Europeo (FSE)
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Background & aims: Epidemiological data suggest that moderate red wine consumption reduces cardiovascular mortality and the incidence of diabetes. However, whether these effects are due to ethanol or to non-alcoholic components of red wine still remains unknown. The aim of the present study was to compare the effects of moderate consumption of red wine, dealcoholized red wine, and gin on glucose metabolism and the lipid profile. Methods: Sixty-seven men at high cardiovascular risk were randomized in a crossover trial. After a run-in period, all received each of red wine (30 g alcohol/d), the equivalent amount of dealcoholized red wine, and gin (30 g alcohol/d) for 4 week periods, in a randomized order. Fasting plasma glucose and insulin, homeostasis model assessment of insulin resistance (HOMA-IR), plasma lipoproteins, apolipoproteins and adipokines were determined at baseline and after each intervention. Results: Fasting glucose remained constant throughout the study, while mean adjusted plasma insulin and HOMA-IR decreased after red wine and dealcoholized red wine. HDL cholesterol, Apolipoprotein A-I and A-II increased after red wine and gin. Lipoprotein(a) decreased after the red wine intervention. Conclusions: These results support a beneficial effect of the non-alcoholic fraction of red wine (mainly polyphenols) on insulin resistance, conferring greater protective effects on cardiovascular disease to red wine than other alcoholic beverages. www.isrctn.org: ISRCTN88720134. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism.
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