Journal
CLINICAL NUTRITION
Volume 28, Issue 3, Pages 249-255Publisher
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2009.03.005
Keywords
Tolerance; Nitrogen balance; Nutritional support; Requirements
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Funding
- DAvW
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Background & aims: Nutritional support improves outcome in critically ill infants but is impeded by fluid restriction, gastric intolerance and feeding interruptions. Protein and energy-enriched infant formulas may help to achieve nutritional targets earlier during admission and promote anabolism. Methods: Randomized controlled design. Infants with respiratory failure due to RSV-bronchiolitis received a protein and energy-enriched formula (PE-formula, n = 8) or a standard formula (S-formula, n = 10) during 5 days after admission. Primary outcome: nutrient delivery, energy and nitrogen balance and plasma amino acid concentrations. Secondary outcome: tolerance and safety. Results: Nutrient intakes were higher in PE fed infants and met population reference intake (PRI) on day 3-5 whilst in S-fed infants PRI was met on day 5 only. Cumulative nitrogen balance (cNB) and energy balance (cEB) were higher in PE-infants compared to S-infants (cNB: 866 +/- 113 vs. 296 +/- 71 mg/kg; cEB: 151 +/- 31 and 26 +/- 17 kcal/kg, both P < 0.01). Essential amino acid levels were higher in PE-infants but within reference limits whereas below these limits in S-infants. Both formulas were well tolerated. Conclusions: Early administration of a protein and energy-enriched formula in critically ill infants is well tolerated, promotes a more adequate nutrient intake and improves energy and nitrogen balance without adverse effects. (C) 2009 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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