Detection of Synchronous Primary Breast and Prostate Cancer by F-18 Fluorocholine PET/CT

There is growing experience with F-18 fluorocholine (FCH) for positron emission tomography/computed tomography (PET/CT) imaging of prostate cancer, but limited experience in breast cancer. We report the PET detection of synchronous cancers of the breast and prostate. A 68-year-old man with elevated prostate specific antigen levels underwent PET/CT following injection of 4.7 mCi of FCH with informed consent as part of a clinical research study. PET/CT revealed focal uptake in the left breast that was found by biopsy to be an invasive ductal breast carcinoma. Prostate biopsy also revealed prostate cancer corresponding to an area of increased prostatic FCH uptake. The patient received primary treatments with mastectomy and prostatectomy.